2ggm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ggm.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ggm.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ggm| PDB=2ggm | SCENE= }}
{{STRUCTURE_2ggm| PDB=2ggm | SCENE= }}
-
'''Human centrin 2 xeroderma pigmentosum group C protein complex'''
+
===Human centrin 2 xeroderma pigmentosum group C protein complex===
-
==Overview==
+
<!--
-
Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To determine the structure of human centrin-2 and to develop an understanding of molecular interactions between centrin and xeroderma pigmentosum group C protein, we characterized the crystal structure of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C peptide. Our structure shows that the carboxyl-terminal domain of centrin-2 binds this peptide and two calcium atoms, whereas the amino-terminal lobe is in a closed conformation positioned distantly by an ordered alpha-helical linker. A stretch of the amino-terminal domain unique to centrins appears disordered. Two xeroderma pigmentosum group C peptides both bound to centrin-2 also interact to form an alpha-helical coiled-coil. The interface between centrin-2 and each peptide is predominantly nonpolar, and key hydrophobic residues of XPC have been identified that lead us to propose a novel binding motif for centrin.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16627479}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16627479 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16627479}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Dna repair complex]]
[[Category: Dna repair complex]]
[[Category: Ef-hand superfamily]]
[[Category: Ef-hand superfamily]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:05:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:40:51 2008''

Revision as of 02:40, 29 July 2008

Image:2ggm.png

Template:STRUCTURE 2ggm

Human centrin 2 xeroderma pigmentosum group C protein complex

Template:ABSTRACT PUBMED 16627479

About this Structure

2GGM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the human centrin 2-xeroderma pigmentosum group C protein complex., Thompson JR, Ryan ZC, Salisbury JL, Kumar R, J Biol Chem. 2006 Jul 7;281(27):18746-52. Epub 2006 Apr 20. PMID:16627479

Page seeded by OCA on Tue Jul 29 05:40:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ggm"
Personal tools