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2gh0

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[[Image:2gh0.gif|left|200px]]
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{{STRUCTURE_2gh0| PDB=2gh0 | SCENE= }}
{{STRUCTURE_2gh0| PDB=2gh0 | SCENE= }}
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'''Growth factor/receptor complex'''
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===Growth factor/receptor complex===
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==Overview==
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Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications.
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The line below this paragraph, {{ABSTRACT_PUBMED_16765900}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16765900 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16765900}}
==About this Structure==
==About this Structure==
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[[Category: Cystine-knot]]
[[Category: Cystine-knot]]
[[Category: Helix bundle]]
[[Category: Helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:05:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:36:15 2008''

Revision as of 00:36, 28 July 2008

Image:2gh0.png

Template:STRUCTURE 2gh0

Growth factor/receptor complex

Template:ABSTRACT PUBMED 16765900

About this Structure

2GH0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors., Wang X, Baloh RH, Milbrandt J, Garcia KC, Structure. 2006 Jun;14(6):1083-92. PMID:16765900

Page seeded by OCA on Mon Jul 28 03:36:15 2008

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