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| | {{STRUCTURE_2gi7| PDB=2gi7 | SCENE= }} | | {{STRUCTURE_2gi7| PDB=2gi7 | SCENE= }} |
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| - | '''Crystal structure of human platelet Glycoprotein VI (GPVI)'''
| + | ===Crystal structure of human platelet Glycoprotein VI (GPVI)=== |
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| - | ==Overview==
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| - | Activation of circulating platelets by exposed vessel wall collagen is a primary step in the pathogenesis of heart attack and stroke, and drugs to block platelet activation have successfully reduced cardiovascular morbidity and mortality. In humans and mice, collagen activation of platelets is mediated by glycoprotein VI (GPVI), a receptor that is homologous to immune receptors but bears little sequence similarity to known matrix protein adhesion receptors. Here we present the crystal structure of the collagen-binding domain of human GPVI and characterize its interaction with a collagen-related peptide. Like related immune receptors, GPVI contains 2 immunoglobulin-like domains arranged in a perpendicular orientation. Significantly, GPVI forms a back-to-back dimer in the crystal, an arrangement that could explain data previously obtained from cell-surface GPVI inhibition studies. Docking algorithms identify 2 parallel grooves on the GPVI dimer surface as collagen-binding sites, and the orientation and spacing of these grooves precisely match the dimensions of an intact collagen fiber. These findings provide a structural basis for the ability of an immune-type receptor to generate signaling responses to collagen and for the development of GPVI inhibitors as new therapies for human cardiovascular disease.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_16861347}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 16861347 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_16861347}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Kahn, M L.]] | | [[Category: Kahn, M L.]] |
| | [[Category: Ig-like domain]] | | [[Category: Ig-like domain]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:08:09 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:32:56 2008'' |
Revision as of 12:32, 29 July 2008
Template:STRUCTURE 2gi7
Crystal structure of human platelet Glycoprotein VI (GPVI)
Template:ABSTRACT PUBMED 16861347
About this Structure
2GI7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI., Horii K, Kahn ML, Herr AB, Blood. 2006 Aug 1;108(3):936-42. PMID:16861347
Page seeded by OCA on Tue Jul 29 15:32:56 2008
