2giy

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{{STRUCTURE_2giy| PDB=2giy | SCENE= }}
{{STRUCTURE_2giy| PDB=2giy | SCENE= }}
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'''Crystal Structure of the C-terminal domain of the HSV-1 gE ectodomain'''
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===Crystal Structure of the C-terminal domain of the HSV-1 gE ectodomain===
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==Overview==
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Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the cell-to-cell spread of virus. gE-gI binds immunoglobulin G at the basic pH of the cell surface and releases it at the acidic pH of lysosomes, consistent with a role in facilitating the degradation of antiviral antibodies. Here we identify the C-terminal domain of the gE ectodomain (CgE) as the minimal Fc-binding domain and present a 1.78-angstroms CgE structure. A 5-angstroms gE-gI/Fc crystal structure, which was independently verified by a theoretical prediction method, reveals that CgE binds Fc at the C(H)2-C(H)3 interface, the binding site for several mammalian and bacterial Fc-binding proteins. The structure identifies interface histidines that may confer pH-dependent binding and regions of CgE implicated in cell-to-cell spread of virus. The ternary organization of the gE-gI/Fc complex is compatible with antibody bipolar bridging, which can interfere with the antiviral immune response.
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The line below this paragraph, {{ABSTRACT_PUBMED_16646632}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16646632 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16646632}}
==About this Structure==
==About this Structure==
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[[Category: Ig v domain]]
[[Category: Ig v domain]]
[[Category: Viral fc receptor]]
[[Category: Viral fc receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:38:28 2008''

Revision as of 23:38, 27 July 2008

Image:2giy.png

Template:STRUCTURE 2giy

Crystal Structure of the C-terminal domain of the HSV-1 gE ectodomain

Template:ABSTRACT PUBMED 16646632

About this Structure

2GIY is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:16646632

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