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2gku

From Proteopedia

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{{STRUCTURE_2gku| PDB=2gku | SCENE= }}
{{STRUCTURE_2gku| PDB=2gku | SCENE= }}
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'''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures'''
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===Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures===
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==Overview==
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We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 16866556 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16866556}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
==Reference==
==Reference==
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[[Category: G-tetrad]]
[[Category: G-tetrad]]
[[Category: Nmr,12 structure]]
[[Category: Nmr,12 structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:13:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:46:56 2008''

Revision as of 21:46, 28 July 2008

Image:2gku.png

Template:STRUCTURE 2gku

Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures

Template:ABSTRACT PUBMED 16866556

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556

Page seeded by OCA on Tue Jul 29 00:46:56 2008

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