2odd
From Proteopedia
(New page: 200px<br /> <applet load="2odd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2odd" /> '''Solution structure of the MYND domain from ...) |
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'''Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor'''<br /> | '''Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ODD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2ODD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: proline-tryptophan interaction]] | [[Category: proline-tryptophan interaction]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:28:48 2008'' |
Revision as of 12:28, 23 January 2008
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Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor
Overview
AML1/ETO results from the t(8;21) associated with 12%-15% of acute myeloid, leukemia. The AML1/ETO MYND domain mediates interactions with the, corepressors SMRT and N-CoR and contributes to AML1/ETO's ability to, repress proliferation and differentiation of primary bone marrow cells as, well as to enhance their self renewal in vitro. We solved the solution, structure of the MYND domain and show it to be structurally homologous to, the PHD and RING finger families of proteins. We also determined the, solution structure of an MYND-SMRT peptide complex. We demonstrated that a, single amino acid substitution that disrupts the interaction between the, MYND domain and the SMRT peptide attenuated AML1/ETO's effects on, proliferation, differentiation, and gene expression.
About this Structure
2ODD is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity., Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH, Cancer Cell. 2007 Jun;11(6):483-97. PMID:17560331
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