2glw

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[[Image:2glw.gif|left|200px]]
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{{Seed}}
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[[Image:2glw.png|left|200px]]
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{{STRUCTURE_2glw| PDB=2glw | SCENE= }}
{{STRUCTURE_2glw| PDB=2glw | SCENE= }}
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'''The solution structure of PHS018 from pyrococcus horikoshii'''
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===The solution structure of PHS018 from pyrococcus horikoshii===
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==Overview==
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The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
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The line below this paragraph, {{ABSTRACT_PUBMED_17027498}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17027498 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17027498}}
==About this Structure==
==About this Structure==
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2GLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA].
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2GLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Rift barrel]]
[[Category: Rift barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:15:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:18:57 2008''

Revision as of 13:19, 28 July 2008

Image:2glw.png

Template:STRUCTURE 2glw

The solution structure of PHS018 from pyrococcus horikoshii

Template:ABSTRACT PUBMED 17027498

About this Structure

2GLW is a Single protein structure of sequence from Pyrococcus horikoshii. Full experimental information is available from OCA.

Reference

Common evolutionary origin of swapped-hairpin and double-psi beta barrels., Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, Lupas AN, Structure. 2006 Oct;14(10):1489-98. PMID:17027498

Page seeded by OCA on Mon Jul 28 16:18:57 2008

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