2gm4

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{{STRUCTURE_2gm4| PDB=2gm4 | SCENE= }}
{{STRUCTURE_2gm4| PDB=2gm4 | SCENE= }}
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'''An activated, tetrameric gamma-delta resolvase: Hin chimaera bound to cleaved DNA'''
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===An activated, tetrameric gamma-delta resolvase: Hin chimaera bound to cleaved DNA===
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==Overview==
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The structures of two mutants of the site-specific recombinase, gammadelta resolvase, that form activated tetramers have been determined. One, at 3.5-A resolution, forms a synaptic intermediate of resolvase that is covalently linked to two cleaved DNAs, whereas the other is of an unliganded structure determined at 2.1-A resolution. Comparisons of the four known tetrameric resolvase structures show that the subunits interact through the formation of a common core of four helices. The N-terminal halves of these helices superimpose well on each other, whereas the orientations of their C termini are more variable. The catalytic domains of resolvase in the unliganded structure are arranged asymmetrically, demonstrating that their positions can move substantially while preserving the four-helix core that forms the tetramer. These results suggest that the precleavage synaptic tetramer of gammadelta resolvase, whose structure is not known, may be formed by a similar four-helix core, but differ in the relative orientations of its catalytic and DNA-binding domains.
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{{ABSTRACT_PUBMED_16807292}}
==About this Structure==
==About this Structure==
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[[Category: Protein dna complex]]
[[Category: Protein dna complex]]
[[Category: Site specific recombination]]
[[Category: Site specific recombination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:15:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:28:53 2008''

Revision as of 16:28, 27 July 2008

Image:2gm4.png

Template:STRUCTURE 2gm4

An activated, tetrameric gamma-delta resolvase: Hin chimaera bound to cleaved DNA

Template:ABSTRACT PUBMED 16807292

About this Structure

2GM4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination., Kamtekar S, Ho RS, Cocco MJ, Li W, Wenwieser SV, Boocock MR, Grindley ND, Steitz TA, Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10642-7. Epub 2006 Jun 28. PMID:16807292

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