2gox

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{{STRUCTURE_2gox| PDB=2gox | SCENE= }}
{{STRUCTURE_2gox| PDB=2gox | SCENE= }}
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'''Crystal structure of Efb-C / C3d Complex'''
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===Crystal structure of Efb-C / C3d Complex===
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==Overview==
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To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.
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(as it appears on PubMed at http://www.pubmed.gov), where 17351618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17351618}}
==Disease==
==Disease==
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[[Category: Cell adhesion/toxin complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:39:33 2008''

Revision as of 19:39, 27 July 2008

Image:2gox.png

Template:STRUCTURE 2gox

Contents

Crystal structure of Efb-C / C3d Complex

Template:ABSTRACT PUBMED 17351618

Disease

Known disease associated with this structure: C3 deficiency OMIM:[120700], Macular degeneration, age-related, 9 OMIM:[120700]

About this Structure

2GOX is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618

Page seeded by OCA on Sun Jul 27 22:39:33 2008

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