2goz

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[[Image:2goz.gif|left|200px]]
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{{Seed}}
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[[Image:2goz.png|left|200px]]
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{{STRUCTURE_2goz| PDB=2goz | SCENE= }}
{{STRUCTURE_2goz| PDB=2goz | SCENE= }}
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'''The 2.2 A structure of a full-length catalytically active hammerhead ribozyme'''
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===The 2.2 A structure of a full-length catalytically active hammerhead ribozyme===
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==Overview==
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Minimal hammerhead ribozymes have been characterized extensively by static and time-resolved crystallography as well as numerous biochemical analyses, leading to mutually contradictory mechanistic explanations for catalysis. We present the 2.2 A resolution crystal structure of a full-length Schistosoma mansoni hammerhead ribozyme that permits us to explain the structural basis for its 1000-fold catalytic enhancement. The full-length hammerhead structure reveals how tertiary interactions occurring remotely from the active site prime this ribozyme for catalysis. G-12 and G-8 are positioned consistent with their previously suggested roles in acid-base catalysis, the nucleophile is aligned with a scissile phosphate positioned proximal to the A-9 phosphate, and previously unexplained roles of other conserved nucleotides become apparent within the context of a distinctly new fold that nonetheless accommodates the previous structural studies. These interactions permit us to explain the previously irreconcilable sets of experimental results in a unified, consistent, and unambiguous manner.
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(as it appears on PubMed at http://www.pubmed.gov), where 16859740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16859740}}
==About this Structure==
==About this Structure==
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[[Category: Stem-loop interaction]]
[[Category: Stem-loop interaction]]
[[Category: Uridine turn]]
[[Category: Uridine turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:21:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:03:59 2008''

Revision as of 10:04, 29 July 2008

Image:2goz.png

Template:STRUCTURE 2goz

The 2.2 A structure of a full-length catalytically active hammerhead ribozyme

Template:ABSTRACT PUBMED 16859740

About this Structure

Full crystallographic information is available from OCA.

Reference

Tertiary contacts distant from the active site prime a ribozyme for catalysis., Martick M, Scott WG, Cell. 2006 Jul 28;126(2):309-20. Epub 2006 Jul 20. PMID:16859740

Page seeded by OCA on Tue Jul 29 13:03:59 2008

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