2gsg

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[[Image:2gsg.jpg|left|200px]]
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{{STRUCTURE_2gsg| PDB=2gsg | SCENE= }}
{{STRUCTURE_2gsg| PDB=2gsg | SCENE= }}
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'''Crystal structure of the Fv fragment of a monoclonal antibody specific for poly-glutamine'''
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===Crystal structure of the Fv fragment of a monoclonal antibody specific for poly-glutamine===
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==Overview==
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Huntington and related neurological diseases result from expansion of a polyglutamine (polyQ) tract. The linear lattice model for the structure and binding properties of polyQ proposes that both expanded and normal polyQ tracts in the preaggregation state are random-coil structures but that an expanded polyQ repeat contains a larger number of epitopes recognized by antibodies or other proteins. The crystal structure of polyQ bound to MW1, an antibody against polyQ, reveals that polyQ adopts an extended, coil-like structure. Consistent with the linear lattice model, multimeric MW1 Fvs bind more tightly to longer than to shorter polyQ tracts and, compared with monomeric Fv, bind expanded polyQ repeats with higher apparent affinities. These results suggest a mechanism for the toxicity of expanded polyQ and a strategy to link anti-polyQ compounds to create high-avidity therapeutics.
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(as it appears on PubMed at http://www.pubmed.gov), where 17450152 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17450152}}
==About this Structure==
==About this Structure==
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[[Category: Monoclonal antibody]]
[[Category: Monoclonal antibody]]
[[Category: Poly-glutamine]]
[[Category: Poly-glutamine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:28:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:25:46 2008''

Revision as of 14:25, 28 July 2008

Image:2gsg.png

Template:STRUCTURE 2gsg

Crystal structure of the Fv fragment of a monoclonal antibody specific for poly-glutamine

Template:ABSTRACT PUBMED 17450152

About this Structure

Full crystallographic information is available from OCA.

Reference

The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model., Li P, Huey-Tubman KE, Gao T, Li X, West AP Jr, Bennett MJ, Bjorkman PJ, Nat Struct Mol Biol. 2007 May;14(5):381-7. Epub 2007 Apr 22. PMID:17450152

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