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2gv2

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{{STRUCTURE_2gv2| PDB=2gv2 | SCENE= }}
{{STRUCTURE_2gv2| PDB=2gv2 | SCENE= }}
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'''MDM2 in complex with an 8-mer p53 peptide analogue'''
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===MDM2 in complex with an 8-mer p53 peptide analogue===
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==Overview==
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The most potent inhibitor of the p53-MDM2 interaction reported to date is an 8-mer p53 peptide analogue (Novartis peptide), which contains 6-chlorotryptophane (Cl-Trp) and phosphonomethylphenylalanine (Pmp) as key residues for the enhanced activity. We report here a crystal structure of the co-complex between MDM2 and the Novartis peptide solved at 1.8 A resolution. The structural basis for the role of the two aromatic residues are delineated by comparing the present structure with crystal structures of the MDM2 co-complex bound to other inhibitors including the wt-p53 peptide itself.
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{{ABSTRACT_PUBMED_16925398}}
==About this Structure==
==About this Structure==
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[[Category: Schubert, C.]]
[[Category: Schubert, C.]]
[[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
[[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:05:59 2008''

Revision as of 18:06, 27 July 2008

Image:2gv2.png

Template:STRUCTURE 2gv2

MDM2 in complex with an 8-mer p53 peptide analogue

Template:ABSTRACT PUBMED 16925398

About this Structure

2GV2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2., Sakurai K, Schubert C, Kahne D, J Am Chem Soc. 2006 Aug 30;128(34):11000-1. PMID:16925398

Page seeded by OCA on Sun Jul 27 21:05:59 2008

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