2gvo

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[[Image:2gvo.gif|left|200px]]
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{{STRUCTURE_2gvo| PDB=2gvo | SCENE= }}
{{STRUCTURE_2gvo| PDB=2gvo | SCENE= }}
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'''Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides'''
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===Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides===
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==Overview==
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A preferential target of antisense oligonucleotides directed against human PGY/MDR1 mRNA is a hairpin containing a stem with a G*U wobble pair, capped by the purine-rich 5'r(GGGAUG)3' hexaloop. This hairpin is studied by multidimensional NMR and restrained molecular dynamics, with special emphasis on the conformation of south sugars and non-standard phosphate linkages evidenced in both the stem and the loop. The hairpin is found to be highly structured. The G*U wobble pair, a strong counterion binding site, displays structural particularities that are characteristic of this type of mismatch. The upper part of the stem undergoes distortions that optimize its interactions with the beginning of the loop. The loop adopts a new fold in which the single-stranded GGGA purine tract is structured in A-like conformation stacked in continuity of the stem and displays an extensive hydrogen bonding surface for recognition. The remarkable hairpin stability results from classical inter- and intra-strand interactions reinforced by numerous hydrogen bonds involving unusual backbone conformations and ribose 2'-hydroxyl groups. Overall, this work emphasizes numerous features that account for the well-ordered structure of the whole hairpin and highlights the loop properties that facilitate interaction with antisense oligonucleotides.
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(as it appears on PubMed at http://www.pubmed.gov), where 17041234 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17041234}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GVO OCA].
==Reference==
==Reference==
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[[Category: Hexaloop]]
[[Category: Hexaloop]]
[[Category: Rna structure]]
[[Category: Rna structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:35:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:32:24 2008''

Revision as of 12:32, 27 July 2008

Image:2gvo.png

Template:STRUCTURE 2gvo

Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides

Template:ABSTRACT PUBMED 17041234

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides., Joli F, Bouchemal N, Laigle A, Hartmann B, Hantz E, Nucleic Acids Res. 2006;34(20):5740-51. Epub 2006 Oct 13. PMID:17041234

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