2opz
From Proteopedia
(New page: 200px<br /> <applet load="2opz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2opz, resolution 3.Å" /> '''AVPF bound to BIR3-XI...) |
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| - | [[Image:2opz.gif|left|200px]]<br /> | + | [[Image:2opz.gif|left|200px]]<br /><applet load="2opz" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2opz" size=" | + | |
caption="2opz, resolution 3.Å" /> | caption="2opz, resolution 3.Å" /> | ||
'''AVPF bound to BIR3-XIAP'''<br /> | '''AVPF bound to BIR3-XIAP'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A small series of peptide mimics was designed and synthesized to contain a | + | A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OPZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2OPZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Wist, A | + | [[Category: Wist, A D.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: bir3 domain of xiap]] | [[Category: bir3 domain of xiap]] | ||
[[Category: tetrapeptide]] | [[Category: tetrapeptide]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:21:14 2008'' |
Revision as of 16:21, 21 February 2008
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AVPF bound to BIR3-XIAP
Contents |
Overview
A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
Disease
Known diseases associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[300079]
About this Structure
2OPZ is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP., Wist AD, Gu L, Riedl SJ, Shi Y, McLendon GL, Bioorg Med Chem. 2007 Apr 15;15(8):2935-43. Epub 2007 Feb 11. PMID:17336535
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