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2h0q

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{{STRUCTURE_2h0q| PDB=2h0q | SCENE= }}
{{STRUCTURE_2h0q| PDB=2h0q | SCENE= }}
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'''Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)'''
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===Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)===
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==Overview==
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Precise signaling by the T cell receptor (TCR) is crucial for a proper immune response. To ensure that T cells respond appropriately to antigenic stimuli, TCR signaling pathways are subject to multiple levels of regulation. Sts-1 negatively regulates signaling pathways downstream of the TCR by an unknown mechanism(s). Here, we demonstrate that Sts-1 is a phosphatase that can target the tyrosine kinase Zap-70 among other proteins. The X-ray structure of the Sts-1 C terminus reveals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) family of enzymes, with residues known to be important for PGM/AcP catalytic activity conserved in nature and position in Sts-1. Point mutations that impair Sts-1 phosphatase activity in vitro also impair the ability of Sts-1 to regulate TCR signaling in T cells. These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling.
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(as it appears on PubMed at http://www.pubmed.gov), where 17679096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17679096}}
==About this Structure==
==About this Structure==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Sts-1]]
[[Category: Sts-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:43:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:42:21 2008''

Revision as of 09:42, 29 July 2008

Image:2h0q.png

Template:STRUCTURE 2h0q

Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)

Template:ABSTRACT PUBMED 17679096

About this Structure

2H0Q is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:17679096

Page seeded by OCA on Tue Jul 29 12:42:21 2008

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