2h2m

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{{STRUCTURE_2h2m| PDB=2h2m | SCENE= }}
{{STRUCTURE_2h2m| PDB=2h2m | SCENE= }}
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'''Solution Structure of the N-terminal domain of COMMD1 (Murr1)'''
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===Solution Structure of the N-terminal domain of COMMD1 (Murr1)===
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==Overview==
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COMMD1 is the prototype of a new protein family that plays a role in several important cellular processes, including NF-kappaB signaling, sodium transport, and copper metabolism. The COMMD proteins interact with one another via a conserved C-terminal domain, whereas distinct functions are predicted to result from a variable N-terminal domain. The COMMD proteins have not been characterized biochemically or structurally. Here, we present the solution structure of the N-terminal domain of COMMD1 (N-COMMD1, residues 1-108). This domain adopts an alpha-helical structure that bears little resemblance to any other helical protein. The compact nature of N-COMMD1 suggests that full-length COMMD proteins are modular, consistent with specific functional properties for each domain. Interactions between N-COMMD1 and partner proteins may occur via complementary electrostatic surfaces. These data provide a new foundation for biochemical characterization of COMMD proteins and for probing COMMD1 protein-protein interactions at the molecular level.
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{{ABSTRACT_PUBMED_17097678}}
==About this Structure==
==About this Structure==
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2H2M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2M OCA].
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2H2M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2M OCA].
==Reference==
==Reference==
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[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
[[Category: All alpha-helical]]
[[Category: All alpha-helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:47:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:56:59 2008''

Revision as of 23:57, 28 July 2008

Image:2h2m.png

Template:STRUCTURE 2h2m

Solution Structure of the N-terminal domain of COMMD1 (Murr1)

Template:ABSTRACT PUBMED 17097678

About this Structure

2H2M is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the COMMD1 N-terminal domain., Sommerhalter M, Zhang Y, Rosenzweig AC, J Mol Biol. 2007 Jan 19;365(3):715-21. Epub 2006 Oct 13. PMID:17097678

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