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2h2t

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[[Image:2h2t.gif|left|200px]]
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{{STRUCTURE_2h2t| PDB=2h2t | SCENE= }}
{{STRUCTURE_2h2t| PDB=2h2t | SCENE= }}
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'''CD23 Lectin domain, Calcium 2+-bound'''
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===CD23 Lectin domain, Calcium 2+-bound===
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==Overview==
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CD23, the low-affinity receptor for IgE (Fc epsilonRII), regulates IgE synthesis and also mediates IgE-dependent antigen transport and processing. CD23 is a unique Fc receptor belonging to the C-type lectin-like domain superfamily and binds IgE in an unusual, non-lectin-like manner, requiring calcium but not carbohydrate. We have solved the high-resolution crystal structures of the human CD23 lectin domain in the presence and absence of Ca2+. The crystal structures differ significantly from a previously determined NMR structure and show that calcium binding occurs at the principal binding site, but not at an auxiliary site that appears to be absent in human CD23. Conformational differences between the apo and Ca2+ bound structures suggest how IgE-Fc binding can be both calcium-dependent and carbohydrate-independent.
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(as it appears on PubMed at http://www.pubmed.gov), where 16765898 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16765898}}
==About this Structure==
==About this Structure==
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[[Category: Lectin domain]]
[[Category: Lectin domain]]
[[Category: Low affinity ige receptor]]
[[Category: Low affinity ige receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:48:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:50:03 2008''

Revision as of 09:50, 28 July 2008

Image:2h2t.png

Template:STRUCTURE 2h2t

CD23 Lectin domain, Calcium 2+-bound

Template:ABSTRACT PUBMED 16765898

About this Structure

2H2T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding., Wurzburg BA, Tarchevskaya SS, Jardetzky TS, Structure. 2006 Jun;14(6):1049-58. PMID:16765898

Page seeded by OCA on Mon Jul 28 12:50:03 2008

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