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2h2x

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{{Seed}}
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{{STRUCTURE_2h2x| PDB=2h2x | SCENE= }}
{{STRUCTURE_2h2x| PDB=2h2x | SCENE= }}
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'''Solution structure of the Tetrahymena telomerase RNA stem IV terminal loop'''
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===Solution structure of the Tetrahymena telomerase RNA stem IV terminal loop===
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==Overview==
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Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem-loop IV domain, which is involved in both catalysis and RNP assembly, and includes binding sites for both the holoenzyme assembly protein p65 and telomerase reverse transcriptase (TERT). Stem-loop IV contains two regions with high evolutionary sequence conservation: a central GA bulge between helices, and a terminal loop. We solved the solution structure of loop IV and modeled the structure of the helical region containing the GA bulge, using NMR and residual dipolar couplings. The central GA bulge with flanking C-G base pairs induces a approximately 50 degrees semi-rigid bend in the helix. Loop IV is highly structured, and contains a conserved C-U base pair at the top of the helical stem. Analysis of new and previous biochemical data in light of the structure provides a rationale for some of the sequence conservation in this region of TER. The results suggest that during holoenzyme assembly the protein p65 recognizes a bend in stem IV, and this binding to central stem IV helps to position the structured loop IV for interaction with TERT and other region(s) of TER.
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(as it appears on PubMed at http://www.pubmed.gov), where 16809815 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16809815}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2X OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2X OCA].
==Reference==
==Reference==
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[[Category: C-u base pair]]
[[Category: C-u base pair]]
[[Category: Heptaloop]]
[[Category: Heptaloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:48:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:51:28 2008''

Revision as of 07:51, 28 July 2008

Image:2h2x.png

Template:STRUCTURE 2h2x

Solution structure of the Tetrahymena telomerase RNA stem IV terminal loop

Template:ABSTRACT PUBMED 16809815

About this Structure

Full experimental information is available from OCA.

Reference

Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function., Richards RJ, Wu H, Trantirek L, O'Connor CM, Collins K, Feigon J, RNA. 2006 Aug;12(8):1475-85. Epub 2006 Jun 29. PMID:16809815

Page seeded by OCA on Mon Jul 28 10:51:28 2008

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