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2h32

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{{STRUCTURE_2h32| PDB=2h32 | SCENE= }}
{{STRUCTURE_2h32| PDB=2h32 | SCENE= }}
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'''Crystal structure of the pre-B cell receptor'''
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===Crystal structure of the pre-B cell receptor===
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==Overview==
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The pre-B cell receptor (pre-BCR) serves as a checkpoint in B cell development. In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire. Biochemical analysis indicates that the pre-BCR is impaired in its ability to recognize antigen, which, together with electron microscopic visualization of a pre-BCR dimer, suggests ligand-independent oligomerization as the likely signaling mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 17431183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17431183}}
==About this Structure==
==About this Structure==
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[[Category: Beta sheet]]
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[[Category: V and c-type ig fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:48:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:03:34 2008''

Revision as of 04:04, 29 July 2008

Image:2h32.png

Template:STRUCTURE 2h32

Crystal structure of the pre-B cell receptor

Template:ABSTRACT PUBMED 17431183

About this Structure

2H32 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insight into pre-B cell receptor function., Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC, Science. 2007 Apr 13;316(5822):291-4. PMID:17431183

Page seeded by OCA on Tue Jul 29 07:03:34 2008

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