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2ot8
From Proteopedia
(New page: 200px<br /> <applet load="2ot8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ot8, resolution 3.1Å" /> '''Karyopherin Beta2/Tr...) |
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| - | [[Image:2ot8.gif|left|200px]]<br /> | + | [[Image:2ot8.gif|left|200px]]<br /><applet load="2ot8" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2ot8" size=" | + | |
caption="2ot8, resolution 3.1Å" /> | caption="2ot8, resolution 3.1Å" /> | ||
'''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''<br /> | '''Karyopherin Beta2/Transportin-hnRNPM NLS Complex'''<br /> | ||
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==Overview== | ==Overview== | ||
Kapbeta2 (also called transportin) recognizes PY nuclear localization, signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we, show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as, classified by the composition of an additional N-terminal motif, converge, in structure only at consensus motifs, which explains ligand diversity. On, the basis of these data and complementary biochemical analyses, we, designed a Kapbeta2-specific nuclear import inhibitor, M9M. | Kapbeta2 (also called transportin) recognizes PY nuclear localization, signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we, show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as, classified by the composition of an additional N-terminal motif, converge, in structure only at consensus motifs, which explains ligand diversity. On, the basis of these data and complementary biochemical analyses, we, designed a Kapbeta2-specific nuclear import inhibitor, M9M. | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Deafness, mitochondrial, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610230 610230]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2OT8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2OT8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OT8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nuclear import complex]] | [[Category: nuclear import complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:43:08 2008'' |
Revision as of 11:43, 23 January 2008
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Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Overview
Kapbeta2 (also called transportin) recognizes PY nuclear localization, signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we, show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as, classified by the composition of an additional N-terminal motif, converge, in structure only at consensus motifs, which explains ligand diversity. On, the basis of these data and complementary biochemical analyses, we, designed a Kapbeta2-specific nuclear import inhibitor, M9M.
About this Structure
2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768
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