2h3b

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{{STRUCTURE_2h3b| PDB=2h3b | SCENE= }}
{{STRUCTURE_2h3b| PDB=2h3b | SCENE= }}
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'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1'''
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===Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1===
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==Overview==
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Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
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{{ABSTRACT_PUBMED_16783373}}
==About this Structure==
==About this Structure==
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[[Category: Apoenzyme]]
[[Category: Apoenzyme]]
[[Category: Type ii phsophoribosyltransferase]]
[[Category: Type ii phsophoribosyltransferase]]
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Revision as of 00:11, 29 July 2008

Image:2h3b.png

Template:STRUCTURE 2h3b

Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1

Template:ABSTRACT PUBMED 16783373

About this Structure

2H3B is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373

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