2h6g

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{{STRUCTURE_2h6g| PDB=2h6g | SCENE= }}
{{STRUCTURE_2h6g| PDB=2h6g | SCENE= }}
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'''W102T Protein Farnesyltransferase Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 1.85A Resolution'''
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===W102T Protein Farnesyltransferase Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 1.85A Resolution===
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==Overview==
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Posttranslational modifications are essential for the proper function of a number of proteins in the cell. One such modification, the covalent attachment of a single isoprenoid lipid (prenylation), is carried out by the CaaX prenyltransferases, protein farnesyltransferase (FTase) and protein geranylgeranyltransferase type-I (GGTase-I). Substrate proteins of these two enzymes are involved in a variety of cellular functions but are largely associated with signal transduction. These modified proteins include members of the Ras superfamily, heterotrimeric G-proteins, centromeric proteins, and a number of proteins involved in nuclear integrity. Although FTase and GGTase-I are highly homologous, they are quite selective for their substrates, particularly for their isoprenoid diphosphate substrates, FPP and GGPP, respectively. Here, we present both crystallographic and kinetic analyses of mutants designed to explore this isoprenoid specificity and demonstrate that this specificity is dependent upon two enzyme residues in the beta subunits of the enzymes, W102beta and Y365beta in FTase (T49beta and F324beta, respectively, in GGTase-I).
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(as it appears on PubMed at http://www.pubmed.gov), where 16893176 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16893176}}
==About this Structure==
==About this Structure==
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[[Category: Ra]]
[[Category: Ra]]
[[Category: Substrate selectivity]]
[[Category: Substrate selectivity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:55:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:31:26 2008''

Revision as of 18:31, 27 July 2008

Image:2h6g.png

Template:STRUCTURE 2h6g

W102T Protein Farnesyltransferase Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 1.85A Resolution

Template:ABSTRACT PUBMED 16893176

About this Structure

2H6G is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conversion of protein farnesyltransferase to a geranylgeranyltransferase., Terry KL, Casey PJ, Beese LS, Biochemistry. 2006 Aug 15;45(32):9746-55. PMID:16893176

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