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2h8r

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[[Image:2h8r.gif|left|200px]]
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{{STRUCTURE_2h8r| PDB=2h8r | SCENE= }}
{{STRUCTURE_2h8r| PDB=2h8r | SCENE= }}
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'''Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product'''
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===Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product===
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==Overview==
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HNF1beta is an atypical POU transcription factor that participates in a hierarchical network of transcription factors controlling the development and proper function of vital organs such as liver, pancreas, and kidney. Many inheritable mutations on HNF1beta are the monogenic causes of diabetes and several kidney diseases. To elucidate the molecular mechanism of its function and the structural basis of mutations, we have determined the crystal structure of human HNF1beta DNA binding domain in complex with a high-affinity promoter. Disease-causing mutations have been mapped to our structure, and their predicted effects have been tested by a set of biochemical/ functional studies. These findings together with earlier findings with a homologous protein HNF1alpha, help us to understand the structural basis of promoter recognition by these atypical POU transcription factors and the site-specific functional disruption by disease-causing mutations.
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(as it appears on PubMed at http://www.pubmed.gov), where 17924661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17924661}}
==About this Structure==
==About this Structure==
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[[Category: Transcription activator/dna complex]]
[[Category: Transcription activator/dna complex]]
[[Category: Trasncription factor]]
[[Category: Trasncription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:00:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:28:31 2008''

Revision as of 03:28, 28 July 2008

Image:2h8r.png

Template:STRUCTURE 2h8r

Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product

Template:ABSTRACT PUBMED 17924661

About this Structure

2H8R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta., Lu P, Rha GB, Chi YI, Biochemistry. 2007 Oct 30;46(43):12071-80. Epub 2007 Oct 9. PMID:17924661

Page seeded by OCA on Mon Jul 28 06:28:31 2008

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