2h9s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2h9s.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2h9s.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2h9s| PDB=2h9s | SCENE= }}
{{STRUCTURE_2h9s| PDB=2h9s | SCENE= }}
-
'''Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System'''
+
===Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System===
-
==Overview==
+
<!--
-
An experimental rationalization of the structure type encountered in DNA and RNA by systematically investigating the chemical and physical properties of alternative nucleic acids has identified systems with a variety of sugar-phosphate backbones that are capable of Watson-Crick base pairing and in some cases cross-pairing with the natural nucleic acids. The earliest among the model systems tested to date, (4' --&gt; 6')-linked oligo(2',3'-dideoxy-beta-d-glucopyranosyl)nucleotides or homo-DNA, shows stable self-pairing, but the pairing rules for the four natural bases are not the same as those in DNA. However, a complete interpretation and understanding of the properties of the hexapyranosyl (4' --&gt; 6') family of nucleic acids has been impeded until now by the lack of detailed 3D-structural data. We have determined the crystal structure of a homo-DNA octamer. It reveals a weakly twisted right-handed duplex with a strong inclination between the hexose-phosphate backbones and base-pair axes, and highly irregular values for helical rise and twist at individual base steps. The structure allows a rationalization of the inability of allo-, altro-, and glucopyranosyl-based oligonucleotides to form stable pairing systems.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16910680}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16910680 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16910680}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Homo-dna]]
[[Category: Homo-dna]]
[[Category: Homo-dna crystal structure]]
[[Category: Homo-dna crystal structure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:01:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:43:11 2008''

Revision as of 13:43, 27 July 2008

Image:2h9s.png

Template:STRUCTURE 2h9s

Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

Template:ABSTRACT PUBMED 16910680

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system., Egli M, Pallan PS, Pattanayek R, Wilds CJ, Lubini P, Minasov G, Dobler M, Leumann CJ, Eschenmoser A, J Am Chem Soc. 2006 Aug 23;128(33):10847-56. PMID:16910680

Page seeded by OCA on Sun Jul 27 16:43:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2h9s"
Personal tools