2h9v

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{{STRUCTURE_2h9v| PDB=2h9v | SCENE= }}
{{STRUCTURE_2h9v| PDB=2h9v | SCENE= }}
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'''Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632'''
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===Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632===
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==Overview==
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Rho-kinase is a main player in the regulation of cytoskeletal events and a promising drug target in the treatment of both vascular and neurological disorders. Here we report the crystal structure of the Rho-kinase catalytic domain in complex with the specific inhibitor Y-27632. Comparison with the structure of PKA bound to this inhibitor revealed a potential induced-fit binding mode that can be accommodated by the phosphate binding loop. This binding mode resembles to that observed in the Rho-kinase-fasudil complex. A structural database search indicated that a pocket underneath the phosphate-binding loop is present that favors binding to a small aromatic ring. Introduction of such a ring group might spawn a new modification scheme of pre-existing protein kinase inhibitors for improved binding capability.
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(as it appears on PubMed at http://www.pubmed.gov), where 16891330 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16891330}}
==About this Structure==
==About this Structure==
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[[Category: Yamaguchi, H.]]
[[Category: Yamaguchi, H.]]
[[Category: Protein kinase-inhibitor complex]]
[[Category: Protein kinase-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:02:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:08:37 2008''

Revision as of 12:08, 28 July 2008

Image:2h9v.png

Template:STRUCTURE 2h9v

Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632

Template:ABSTRACT PUBMED 16891330

About this Structure

2H9V is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632., Yamaguchi H, Miwa Y, Kasa M, Kitano K, Amano M, Kaibuchi K, Hakoshima T, J Biochem. 2006 Sep;140(3):305-11. Epub 2006 Aug 4. PMID:16891330

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