2haj

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{{STRUCTURE_2haj| PDB=2haj | SCENE= }}
{{STRUCTURE_2haj| PDB=2haj | SCENE= }}
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'''Solution structure of the helicase-binding domain of Escherichia coli primase'''
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===Solution structure of the helicase-binding domain of Escherichia coli primase===
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==Overview==
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DnaG is the primase that lays down RNA primers on single-stranded DNA during bacterial DNA replication. The solution structure of the DnaB-helicase-binding C-terminal domain of Escherichia coli DnaG was determined by NMR spectroscopy at near-neutral pH. The structure is a rare fold that, besides occurring in DnaG C-terminal domains, has been described only for the N-terminal domain of DnaB. The C-terminal helix hairpin present in the DnaG C-terminal domain, however, is either less stable or absent in DnaB, as evidenced by high mobility of the C-terminal 35 residues in a construct comprising residues 1-171. The present structure identifies the previous crystal structure of the E. coli DnaG C-terminal domain as a domain-swapped dimer. It is also significantly different from the NMR structure reported for the corresponding domain of DnaG from the thermophile Bacillus stearothermophilus. NMR experiments showed that the DnaG C-terminal domain does not bind to residues 1-171 of the E. coli DnaB helicase with significant affinity.
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{{ABSTRACT_PUBMED_17010164}}
==About this Structure==
==About this Structure==
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2HAJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAJ OCA].
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2HAJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAJ OCA].
==Reference==
==Reference==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Primase]]
[[Category: Primase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:00:39 2008''

Revision as of 03:00, 29 July 2008

Image:2haj.png

Template:STRUCTURE 2haj

Solution structure of the helicase-binding domain of Escherichia coli primase

Template:ABSTRACT PUBMED 17010164

About this Structure

2HAJ is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Monomeric solution structure of the helicase-binding domain of Escherichia coli DnaG primase., Su XC, Schaeffer PM, Loscha KV, Gan PH, Dixon NE, Otting G, FEBS J. 2006 Nov;273(21):4997-5009. Epub 2006 Sep 28. PMID:17010164

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