2hak

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{{STRUCTURE_2hak| PDB=2hak | SCENE= }}
{{STRUCTURE_2hak| PDB=2hak | SCENE= }}
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'''Catalytic and ubiqutin-associated domains of MARK1/PAR-1'''
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===Catalytic and ubiqutin-associated domains of MARK1/PAR-1===
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==Overview==
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The microtubule-associated protein (MAP)/microtubule affinity regulating kinase (MARK)/Par-1 phosphorylates microtubule-associated proteins tau, MAP2, and MAP4 and is involved in the regulation of microtubule-based transport. Par-1, a homologue of MARK in Drosophila and Caenorhabditis elegans, is essential for the development of embryonic polarity. Four isoforms of MARK are found in humans. Recently, we reported the crystal structure of the catalytic and ubiquitin-associated domains of MARK2, an isoform enriched in brain (Panneerselvam, S., Marx, A., Mandelkow, E.-M., and Mandelkow, E. (2006) Structure 14, 173-183). It showed that the ubiquitin-associated domain (UBA) domain has an unusual fold and binds to the N-terminal lobe of the catalytic domain. This is at variance with a previous low resolution structure derived from small angle solution scattering (Jaleel, M., Villa, F., Deak, M., Toth, R., Prescott, A. R., Van Aalten, D. M., and Alessi, D. R. (2006) Biochem. J. 394, 545-555), which predicts binding of the UBA domain to the larger, C-terminal lobe. Here we report the crystal structure of the catalytic and UBA domain of another isoform, MARK1. Although the crystal packing of the two isoforms are unrelated, the overall conformations of the molecules are similar. Notably, the UBA domain has the same unusual conformation as in MARK2, and it binds at the same site. Remarkable differences occur in the catalytic domain at helix C, the catalytic loop, and the activation segment.
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(as it appears on PubMed at http://www.pubmed.gov), where 16803889 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16803889}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2., Marx A, Nugoor C, Muller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow EM, Mandelkow E, J Biol Chem. 2006 Sep 15;281(37):27586-99. Epub 2006 Jun 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16803889 16803889]
Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2., Marx A, Nugoor C, Muller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow EM, Mandelkow E, J Biol Chem. 2006 Sep 15;281(37):27586-99. Epub 2006 Jun 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16803889 16803889]
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Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1., Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E, Structure. 2006 Feb;14(2):173-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16472737 16472737]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Serine/threonine protein kinase]]
[[Category: Serine/threonine protein kinase]]
[[Category: Uba domain]]
[[Category: Uba domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:03:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:01:52 2008''

Revision as of 19:01, 28 July 2008

Image:2hak.png

Template:STRUCTURE 2hak

Catalytic and ubiqutin-associated domains of MARK1/PAR-1

Template:ABSTRACT PUBMED 16803889

About this Structure

2HAK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2., Marx A, Nugoor C, Muller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow EM, Mandelkow E, J Biol Chem. 2006 Sep 15;281(37):27586-99. Epub 2006 Jun 27. PMID:16803889

Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1., Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E, Structure. 2006 Feb;14(2):173-83. PMID:16472737

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