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2hb1

From Proteopedia

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[[Image:2hb1.gif|left|200px]]
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{{STRUCTURE_2hb1| PDB=2hb1 | SCENE= }}
{{STRUCTURE_2hb1| PDB=2hb1 | SCENE= }}
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'''Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor'''
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===Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor===
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==Overview==
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A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
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(as it appears on PubMed at http://www.pubmed.gov), where 16806920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16806920}}
==About this Structure==
==About this Structure==
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:04:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:32:10 2008''

Revision as of 16:32, 27 July 2008

Template:STRUCTURE 2hb1

Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor

Template:ABSTRACT PUBMED 16806920

About this Structure

2HB1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48., Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL, Bioorg Med Chem Lett. 2006 Sep 15;16(18):4941-5. Epub 2006 Jun 27. PMID:16806920

Page seeded by OCA on Sun Jul 27 19:32:10 2008

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