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2hci

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{{STRUCTURE_2hci| PDB=2hci | SCENE= }}
{{STRUCTURE_2hci| PDB=2hci | SCENE= }}
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'''Structure of Human Mip-3a Chemokine'''
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===Structure of Human Mip-3a Chemokine===
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==Overview==
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The structure of the human macrophage inflammatory protein-3alpha (MIP-3alpha) has been determined at 1.81 angstroms resolution by X-ray crystallography. The dimer crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 83.99, c = 57.20 angstroms. The crystals exhibit two molecules in the asymmetric unit. The structure was solved by the molecular-replacement method and the model was refined to a conventional R value of 20.6% (R(free) = 25.7%). MIP-3alpha possesses the same monomeric structure as previously described for other chemokines. However, in addition to limited structural changes in the beta1-beta2 hairpin of monomer B, the electron density is fully defined for a few extra residues at the N- and C-termini of monomer A and the C-terminus of monomer B compared with MIP-3alpha in space group P6(1). As the N-terminal and loop regions have been shown to be critical for receptor binding and signaling, this additional structural information may help in determining the basis of the CCR6 selectivity of MIP-3alpha.
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The line below this paragraph, {{ABSTRACT_PUBMED_16820679}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16820679 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16820679}}
==About this Structure==
==About this Structure==
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[[Category: Macrophage inflammatory protein-3a]]
[[Category: Macrophage inflammatory protein-3a]]
[[Category: Space group i4]]
[[Category: Space group i4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:38:59 2008''

Revision as of 12:39, 29 July 2008

Image:2hci.png

Template:STRUCTURE 2hci

Structure of Human Mip-3a Chemokine

Template:ABSTRACT PUBMED 16820679

About this Structure

2HCI is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of human MIP-3alpha chemokine., Malik ZA, Tack BF, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):631-4. Epub 2006 Jun 30. PMID:16820679

Page seeded by OCA on Tue Jul 29 15:38:59 2008

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