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2hck

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[[Image:2hck.gif|left|200px]]
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[[Image:2hck.png|left|200px]]
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==Overview==
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{{ABSTRACT_9024658}}
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The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
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==About this Structure==
==About this Structure==
2HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2HCK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb43_1.html Src Tyrosine Kinase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCK OCA].
2HCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 2HCK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb43_1.html Src Tyrosine Kinase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCK OCA].
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==Reference==
 
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Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9024658 9024658]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:17:46 2008''

Revision as of 15:17, 26 June 2008

Template:STRUCTURE 2hck

SRC FAMILY KINASE HCK-QUERCETIN COMPLEX


Template:ABSTRACT 9024658

About this Structure

2HCK is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 2HCK with [Src Tyrosine Kinase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:17:46 2008

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