2p23
From Proteopedia
(New page: 200px<br /> <applet load="2p23" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p23, resolution 1.8Å" /> '''Crystal structure of...) |
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caption="2p23, resolution 1.8Å" /> | caption="2p23, resolution 1.8Å" /> | ||
'''Crystal structure of human FGF19'''<br /> | '''Crystal structure of human FGF19'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2P23 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2P23 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P23 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: atypical beta-trefoil fold]] | [[Category: atypical beta-trefoil fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:32:59 2008'' |
Revision as of 13:32, 23 January 2008
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Crystal structure of human FGF19
Overview
Unique among FGFs, fibroblast growth factor (FGF)-19, FGF21 and FGF23 act, in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. These FGFs require the presence of, klotho/betaklotho in their target tissues. Here, we present the crystal, structures of FGF19 alone and of FGF23 in complex with sucrose, octasulfate, a disaccharide chemically related to heparin. The, conformation of the heparin-binding region between beta strands 10 and 12, in FGF19 and FGF23 diverges completely from the common conformation, adopted by paracrine-acting FGFs. A cleft between this region and the, beta1-beta2 loop, the other heparin-binding region, precludes direct, interaction between heparin/heparan sulfate and backbone atoms of, FGF19/23. This reduces the heparin-binding affinity of these ligands and, confers endocrine function. Klotho/betaklotho have evolved as a, compensatory mechanism for the poor ability of heparin/heparan sulfate to, promote binding of FGF19/21/23 to their cognate receptors.
About this Structure
2P23 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of FGF19 Subfamily Members., Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert T, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-O M, Lanske B, Razzaque MS, Mohammadi M, Mol Cell Biol. 2007 Mar 5;. PMID:17339340
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