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2hda

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[[Image:2hda.gif|left|200px]]
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{{STRUCTURE_2hda| PDB=2hda | SCENE= }}
{{STRUCTURE_2hda| PDB=2hda | SCENE= }}
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'''Yes SH3 domain'''
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===Yes SH3 domain===
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==Overview==
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SH3 domains from the Src family of tyrosine kinases represent an interesting example of the delicate balance between promiscuity and specificity characteristic of proline-rich ligand recognition by SH3 domains. The development of inhibitors of therapeutic potential requires a good understanding of the molecular determinants of binding affinity and specificity and relies on the availability of high quality structural information. Here, we present the first high-resolution crystal structure of the SH3 domain of the c-Yes oncogen. Comparison with other SH3 domains from the Src family revealed significant deviations in the loop regions. In particular, the n-Src loop, highly flexible and partially disordered, is stabilized in an unusual conformation by the establishment of several intramolecular hydrogen bonds. Additionally, we present here the first report of amyloid aggregation by an SH3 domain from the Src family.
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(as it appears on PubMed at http://www.pubmed.gov), where 17418139 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17418139}}
==About this Structure==
==About this Structure==
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[[Category: Ruiz-Sanz, J.]]
[[Category: Ruiz-Sanz, J.]]
[[Category: Main beta]]
[[Category: Main beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:08:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:25:38 2008''

Revision as of 16:25, 27 July 2008

Image:2hda.png

Template:STRUCTURE 2hda

Yes SH3 domain

Template:ABSTRACT PUBMED 17418139

About this Structure

2HDA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation., Martin-Garcia JM, Luque I, Mateo PL, Ruiz-Sanz J, Camara-Artigas A, FEBS Lett. 2007 May 1;581(9):1701-6. Epub 2007 Mar 30. PMID:17418139

Page seeded by OCA on Sun Jul 27 19:25:38 2008

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