2hdc

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[[Image:2hdc.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2hdc| PDB=2hdc | SCENE= }}
{{STRUCTURE_2hdc| PDB=2hdc | SCENE= }}
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'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX'''
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===STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX===
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==Overview==
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Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_10369754}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10369754 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10369754}}
==About this Structure==
==About this Structure==
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2HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA].
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2HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA].
==Reference==
==Reference==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: Winged helix protein]]
[[Category: Winged helix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:08:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:16:11 2008''

Revision as of 10:16, 29 July 2008

Image:2hdc.png

Template:STRUCTURE 2hdc

STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX

Template:ABSTRACT PUBMED 10369754

About this Structure

2HDC is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754

Page seeded by OCA on Tue Jul 29 13:16:11 2008

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