2hfp

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{{STRUCTURE_2hfp| PDB=2hfp | SCENE= }}
{{STRUCTURE_2hfp| PDB=2hfp | SCENE= }}
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'''Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands'''
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===Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands===
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==Overview==
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The synthesis and structure-activity relationships of a novel series of N-sulfonyl-2-indole carboxamides that bind to peroxisome proliferator-activated receptor gamma (PPAR-gamma) are reported. Chemical optimization of the series led to the identification of 4q (IC(50)=50 nM) as a potent binding agent of PPAR-gamma. Also reported is preliminary cell based data suggesting the use of these compounds in the treatment of osteoporosis.
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(as it appears on PubMed at http://www.pubmed.gov), where 16919947 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16919947}}
==About this Structure==
==About this Structure==
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[[Category: Walter, R L.]]
[[Category: Walter, R L.]]
[[Category: Ppar ppargamma lbd]]
[[Category: Ppar ppargamma lbd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:14:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:57:13 2008''

Revision as of 13:57, 27 July 2008

Image:2hfp.png

Template:STRUCTURE 2hfp

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

Template:ABSTRACT PUBMED 16919947

About this Structure

2HFP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis., Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP Jr, Bioorg Med Chem Lett. 2006 Nov 1;16(21):5659-63. Epub 2006 Aug 21. PMID:16919947

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