2hio

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[[Image:2hio.gif|left|200px]]
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{{STRUCTURE_2hio| PDB=2hio | SCENE= }}
{{STRUCTURE_2hio| PDB=2hio | SCENE= }}
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'''HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN'''
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===HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN===
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==Overview==
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The structure of the octameric histone core of the nucleosome has been determined by x-ray crystallography to a resolution of 3.1 A. The histone octamer is a tripartite assembly in which a centrally located (H3-H4)2 tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface; depending on the perspective, the structure appears as a wedge or as a flat disk. The disk represents the planar projection of a left-handed proteinaceous superhelix with approximately 28 A pitch. The diameter of the particle is 65 A and the length is 60 A at its maximum and approximately 10 A at its minimum extension; these dimensions are in agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. &amp; Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and are assembled in a characteristic "handshake" motif. The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold.
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(as it appears on PubMed at http://www.pubmed.gov), where 1946434 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1946434}}
==About this Structure==
==About this Structure==
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[[Category: Chromosomal protein]]
[[Category: Chromosomal protein]]
[[Category: Histone]]
[[Category: Histone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:20:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:43:10 2008''

Revision as of 00:43, 29 July 2008

Image:2hio.png

Template:STRUCTURE 2hio

HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN

Template:ABSTRACT PUBMED 1946434

About this Structure

2HIO is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix., Arents G, Burlingame RW, Wang BC, Love WE, Moudrianakis EN, Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10148-52. PMID:1946434

Page seeded by OCA on Tue Jul 29 03:43:10 2008

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