2hiz

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[[Image:2hiz.jpg|left|200px]]
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{{STRUCTURE_2hiz| PDB=2hiz | SCENE= }}
{{STRUCTURE_2hiz| PDB=2hiz | SCENE= }}
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'''Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor'''
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===Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor===
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==Overview==
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We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
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The line below this paragraph, {{ABSTRACT_PUBMED_17046251}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17046251 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17046251}}
==About this Structure==
==About this Structure==
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[[Category: Tomasselli, A G.]]
[[Category: Tomasselli, A G.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:21:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:23:20 2008''

Revision as of 16:23, 28 July 2008

Template:STRUCTURE 2hiz

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor

Template:ABSTRACT PUBMED 17046251

About this Structure

2HIZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design of potent inhibitors of human beta-secretase. Part 1., Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. Epub 2006 Oct 4. PMID:17046251

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