This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hko

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2hko.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2hko.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hko| PDB=2hko | SCENE= }}
{{STRUCTURE_2hko| PDB=2hko | SCENE= }}
-
'''Crystal structure of LSD1'''
+
===Crystal structure of LSD1===
-
==Overview==
+
<!--
-
Lysine-specific demethylase 1 (LSD1) was recently identified as the first histone demethylase that specifically demethylates monomethylated and dimethylated histone H3 at K4. It is a component of the CoREST and other corepressor complexes and plays an important role in silencing neuronal-specific genes in nonneuronal cells, but the molecular mechanisms of its action remain unclear. The 2.8-A-resolution crystal structure of the human LSD1 reveals that LSD1 defines a new subfamily of FAD-dependent oxidases. The active center of LSD1 is characterized by a remarkable 1,245-A3 substrate-binding cavity with a highly negative electrostatic potential. Although the protein core of LSD1 resembles other flavoenzymes, its enzymatic activity and functions require two additional structural modules: an N-terminal SWIRM domain important for protein stability and a large insertion in the catalytic domain indispensable both for the demethylase activity and the interaction with CoREST. These results provide a framework for further probing the catalytic mechanism and the functional roles of LSD1.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16956976}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16956976 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16956976}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Fad binding domain]]
[[Category: Fad binding domain]]
[[Category: Swirm domain]]
[[Category: Swirm domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:24:10 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:27:17 2008''

Revision as of 21:27, 28 July 2008

Image:2hko.png

Template:STRUCTURE 2hko

Crystal structure of LSD1

Template:ABSTRACT PUBMED 16956976

About this Structure

2HKO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human histone lysine-specific demethylase 1 (LSD1)., Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M, Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976

Page seeded by OCA on Tue Jul 29 00:27:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hko"
Personal tools