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2hnq

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{{STRUCTURE_2hnq| PDB=2hnq | SCENE= }}
{{STRUCTURE_2hnq| PDB=2hnq | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B'''
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===CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B===
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==Overview==
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Protein tyrosine phosphatases (PTPs) constitute a family of receptor-like and cytoplasmic signal transducing enzymes that catalyze the dephosphorylation of phosphotyrosine residues and are characterized by homologous catalytic domains. The crystal structure of a representative member of this family, the 37-kilodalton form (residues 1 to 321) of PTP1B, has been determined at 2.8 A resolution. The enzyme consists of a single domain with the catalytic site located at the base of a shallow cleft. The phosphate recognition site is created from a loop that is located at the amino-terminus of an alpha helix. This site is formed from an 11-residue sequence motif that is diagnostic of PTPs and the dual specificity phosphatases, and that contains the catalytically essential cysteine and arginine residues. The position of the invariant cysteine residue within the phosphate binding site is consistent with its role as a nucleophile in the catalytic reaction. The structure of PTP1B should serve as a model for other members of the PTP family and as a framework for understanding the mechanism of tyrosine dephosphorylation.
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The line below this paragraph, {{ABSTRACT_PUBMED_8128219}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8128219 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8128219}}
==About this Structure==
==About this Structure==
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[[Category: Flint, A J.]]
[[Category: Flint, A J.]]
[[Category: Tonks, N K.]]
[[Category: Tonks, N K.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:07:30 2008''

Revision as of 07:07, 28 July 2008

Image:2hnq.png

Template:STRUCTURE 2hnq

CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B

Template:ABSTRACT PUBMED 8128219

About this Structure

2HNQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human protein tyrosine phosphatase 1B., Barford D, Flint AJ, Tonks NK, Science. 1994 Mar 11;263(5152):1397-404. PMID:8128219

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