2ho6

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{{STRUCTURE_2ho6| PDB=2ho6 | SCENE= }}
{{STRUCTURE_2ho6| PDB=2ho6 | SCENE= }}
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'''Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''
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===Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===
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==Overview==
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The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 16990543 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16990543}}
==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:30:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:19:52 2008''

Revision as of 18:19, 27 July 2008

Image:2ho6.png

Template:STRUCTURE 2ho6

Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme

Template:ABSTRACT PUBMED 16990543

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of glmS ribozyme activation by glucosamine-6-phosphate., Klein DJ, Ferre-D'Amare AR, Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543

Page seeded by OCA on Sun Jul 27 21:19:52 2008

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