2hpi

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{{STRUCTURE_2hpi| PDB=2hpi | SCENE= }}
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'''Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III'''
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===Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III===
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==Overview==
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The crystal structure of Thermus aquaticus DNA polymerase III alpha subunit reveals that the structure of the catalytic domain of the eubacterial replicative polymerase is unrelated to that of the eukaryotic replicative polymerase but rather belongs to the Polbeta-like nucleotidyltransferase superfamily. A model of the polymerase complexed with both DNA and beta-sliding clamp interacting with a reoriented binding domain and internal beta binding site was constructed that is consistent with existing biochemical data. Within the crystal, two C-terminal domains are interacting through a surface that is larger than many dimer interfaces. Since replicative polymerases of eubacteria and eukaryotes/archaea are not homologous, the nature of the replicative polymerase in the last common ancestor is unknown. Although other possibilities have been proposed, the plausibility of a ribozyme DNA polymerase should be considered.
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==About this Structure==
==About this Structure==
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[[Category: Wing, R A.]]
[[Category: Wing, R A.]]
[[Category: Pol-beta-like nucleotidyltransferase fold]]
[[Category: Pol-beta-like nucleotidyltransferase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:33:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:10:23 2008''

Revision as of 17:10, 27 July 2008

Image:2hpi.png

Template:STRUCTURE 2hpi

Eubacterial and Eukaryotic Replicative DNA Polymerases are not Homologous: X-ray Structure of DNA Polymerase III

Template:ABSTRACT PUBMED 16959569

About this Structure

2HPI is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases., Bailey S, Wing RA, Steitz TA, Cell. 2006 Sep 8;126(5):893-904. PMID:16959569

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