2hpo

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{{STRUCTURE_2hpo| PDB=2hpo | SCENE= }}
{{STRUCTURE_2hpo| PDB=2hpo | SCENE= }}
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'''Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site'''
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===Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site===
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==Overview==
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Aminopeptidase N from Escherichia coli is a major metalloprotease that participates in the controlled hydrolysis of peptides in the proteolytic pathway. Determination of the 870-aa structure reveals that it has four domains similar to the tricorn-interacting factor F3. The thermolysin-like active site is enclosed within a large cavity with a volume of 2,200 A(3), which is inaccessible to substrates except for a small opening of approximately 8-10 A. The substrate-based inhibitor bestatin binds to the protein with minimal changes, suggesting that this is the active form of the enzyme. The previously described structure of F3 had three distinct conformations that were described as "closed," "intermediate," and "open." The structure of aminopeptidase N from E. coli, however, is substantially more closed than any of these. Taken together, the results suggest that these proteases, which are involved in intracellular peptide degradation, prevent inadvertent hydrolysis of inappropriate substrates by enclosing the active site within a large cavity. There is also some evidence that the open form of the enzyme, which admits substrates, remains inactive until it adopts the closed form.
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(as it appears on PubMed at http://www.pubmed.gov), where 16938892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16938892}}
==About this Structure==
==About this Structure==
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[[Category: Compartmentalized active site]]
[[Category: Compartmentalized active site]]
[[Category: Multidomain]]
[[Category: Multidomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:33:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:48:32 2008''

Revision as of 19:48, 27 July 2008

Image:2hpo.png

Template:STRUCTURE 2hpo

Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site

Template:ABSTRACT PUBMED 16938892

About this Structure

2HPO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site., Addlagatta A, Gay L, Matthews BW, Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13339-44. Epub 2006 Aug 28. PMID:16938892

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