2po6
From Proteopedia
(New page: 200px<br /> <applet load="2po6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2po6, resolution 3.200Å" /> '''Crystal structure ...) |
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| - | [[Image:2po6. | + | [[Image:2po6.jpg|left|200px]]<br /><applet load="2po6" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2po6, resolution 3.200Å" /> | caption="2po6, resolution 3.200Å" /> | ||
'''Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain'''<br /> | '''Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain'''<br /> | ||
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==Overview== | ==Overview== | ||
The CD1 family is a large cluster of non-polymorphic, major, histocompatibility complex (MHC) class-I-like molecules that bind distinct, lipid-based antigens that are recognized by T cells. The most studied, group of T cells that interact with lipid antigens are natural killer T, (NKT) cells, which characteristically express a semi-invariant T-cell, receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been, implicated in microbial immunity, tumour immunity, autoimmunity and, allergy. Here we describe the structure of a human NKT TCR in complex with, CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the, archetypal CD1d-restricted glycolipid. In contrast to T-cell, receptor-peptide-antigen-MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a, lock-and-key type interaction with the lipid antigen. The structure, provides a basis for the interaction between the highly conserved NKT TCR, alpha-chain and the CD1d-antigen complex that is typified in innate, immunity, and also indicates how variability of the NKT TCR beta-chain can, impact on recognition of other CD1d-antigen complexes. These findings, provide direct insight into how a T-cell receptor recognizes a, lipid-antigen-presenting molecule of the immune system. | The CD1 family is a large cluster of non-polymorphic, major, histocompatibility complex (MHC) class-I-like molecules that bind distinct, lipid-based antigens that are recognized by T cells. The most studied, group of T cells that interact with lipid antigens are natural killer T, (NKT) cells, which characteristically express a semi-invariant T-cell, receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been, implicated in microbial immunity, tumour immunity, autoimmunity and, allergy. Here we describe the structure of a human NKT TCR in complex with, CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the, archetypal CD1d-restricted glycolipid. In contrast to T-cell, receptor-peptide-antigen-MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a, lock-and-key type interaction with the lipid antigen. The structure, provides a basis for the interaction between the highly conserved NKT TCR, alpha-chain and the CD1d-antigen complex that is typified in innate, immunity, and also indicates how variability of the NKT TCR beta-chain can, impact on recognition of other CD1d-antigen complexes. These findings, provide direct insight into how a T-cell receptor recognizes a, lipid-antigen-presenting molecule of the immune system. | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2PO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and AGH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2PO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=AGH:'>AGH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PO6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: cd1d-lipid antigen nkt15 complex]] | [[Category: cd1d-lipid antigen nkt15 complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 14:08:23 2008'' |
Revision as of 12:08, 23 January 2008
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Crystal structure of CD1d-lipid-antigen complexed with Beta-2-Microglobulin, NKT15 Alpha-Chain and NKT15 Beta-Chain
Overview
The CD1 family is a large cluster of non-polymorphic, major, histocompatibility complex (MHC) class-I-like molecules that bind distinct, lipid-based antigens that are recognized by T cells. The most studied, group of T cells that interact with lipid antigens are natural killer T, (NKT) cells, which characteristically express a semi-invariant T-cell, receptor (NKT TCR) that specifically recognizes the CD1 family member, CD1d. NKT-cell-mediated recognition of the CD1d-antigen complex has been, implicated in microbial immunity, tumour immunity, autoimmunity and, allergy. Here we describe the structure of a human NKT TCR in complex with, CD1d bound to the potent NKT-cell agonist alpha-galactosylceramide, the, archetypal CD1d-restricted glycolipid. In contrast to T-cell, receptor-peptide-antigen-MHC complexes, the NKT TCR docked parallel to, and at the extreme end of the CD1d-binding cleft, which enables a, lock-and-key type interaction with the lipid antigen. The structure, provides a basis for the interaction between the highly conserved NKT TCR, alpha-chain and the CD1d-antigen complex that is typified in innate, immunity, and also indicates how variability of the NKT TCR beta-chain can, impact on recognition of other CD1d-antigen complexes. These findings, provide direct insight into how a T-cell receptor recognizes a, lipid-antigen-presenting molecule of the immune system.
About this Structure
2PO6 is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor., Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J, Nature. 2007 Jun 20;. PMID:17581592
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