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2hrv

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{{STRUCTURE_2hrv| PDB=2hrv | SCENE= }}
{{STRUCTURE_2hrv| PDB=2hrv | SCENE= }}
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'''2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2'''
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===2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2===
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==Overview==
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The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold comprising a unique four-stranded beta sheet as the N-terminal domain and a six-stranded beta barrel as the C-terminal domain. A tightly bound zinc ion, essential for the stability of HRV2-2A(pro), is tetrahedrally coordinated by three cysteine sulfurs and one histidine nitrogen. The active site consists of a catalytic triad formed by His18, Asp35 and Cys106. Asp35 is additionally involved in an extensive hydrogen-bonding network. Modelling studies reveal a substrate-induced fit that explains the specificity of the subsites S4, S2, S1 and S1'. The structure of HRV2-2A(pro) suggests the mechanism of the cis cleavage and its release from the polyprotein.
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{{ABSTRACT_PUBMED_10523291}}
==About this Structure==
==About this Structure==
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[[Category: Petersen, J F.W.]]
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[[Category: Skern, T.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:38:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:06:24 2008''

Revision as of 17:06, 27 July 2008

Image:2hrv.png

Template:STRUCTURE 2hrv

2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2

Template:ABSTRACT PUBMED 10523291

About this Structure

2HRV is a Single protein structure of sequence from Human rhinovirus 2. Full crystallographic information is available from OCA.

Reference

The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis., Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James MN, EMBO J. 1999 Oct 15;18(20):5463-75. PMID:10523291

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