2htb

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{{STRUCTURE_2htb| PDB=2htb | SCENE= }}
{{STRUCTURE_2htb| PDB=2htb | SCENE= }}
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'''Crystal Structure of a putative mutarotase (YeaD) from Salmonella typhimurium in monoclinic form'''
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===Crystal Structure of a putative mutarotase (YeaD) from Salmonella typhimurium in monoclinic form===
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==Overview==
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Salmonella typhimurium YeaD (stYeaD), annotated as a putative aldose 1-epimerase, has a very low sequence identity to other well characterized mutarotases. Sequence analysis suggested that the catalytic residues and a few of the substrate-binding residues of galactose mutarotases (GalMs) are conserved in stYeaD. Determination of the crystal structure of stYeaD in an orthorhombic form at 1.9 A resolution and in a monoclinic form at 2.5 A resolution revealed this protein to adopt the beta-sandwich fold similar to GalMs. Structural comparison of stYeaD with GalMs has permitted the identification of residues involved in catalysis and substrate binding. In spite of the similar fold and conservation of catalytic residues, minor but significant differences were observed in the substrate-binding pocket. These analyses pointed out the possible role of Arg74 and Arg99, found only in YeaD-like proteins, in ligand anchoring and suggested that the specificity of stYeaD may be distinct from those of GalMs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17242513 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17242513}}
==About this Structure==
==About this Structure==
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[[Category: Sugar phosphate]]
[[Category: Sugar phosphate]]
[[Category: Yead]]
[[Category: Yead]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:41:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:06:50 2008''

Revision as of 00:06, 29 July 2008

Image:2htb.png

Template:STRUCTURE 2htb

Crystal Structure of a putative mutarotase (YeaD) from Salmonella typhimurium in monoclinic form

Template:ABSTRACT PUBMED 17242513

About this Structure

2HTB is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Structure of the putative mutarotase YeaD from Salmonella typhimurium: structural comparison with galactose mutarotases., Chittori S, Simanshu DK, Savithri HS, Murthy MR, Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):197-205. Epub 2007, Jan 16. PMID:17242513

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