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2hu9

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{{STRUCTURE_2hu9| PDB=2hu9 | SCENE= }}
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'''X-ray structure of the Archaeoglobus fulgidus CopZ N-terminal Domain'''
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===X-ray structure of the Archaeoglobus fulgidus CopZ N-terminal Domain===
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==Overview==
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Bacterial CopZ proteins deliver copper to P1B-type Cu+-ATPases that are homologous to the human Wilson and Menkes disease proteins. The genome of the hyperthermophile Archaeoglobus fulgidus encodes a putative CopZ copper chaperone that contains an unusual cysteine-rich N-terminal domain of 130 amino acids in addition to a C-terminal copper binding domain with a conserved CXXC motif. The N-terminal domain (CopZ-NT) is homologous to proteins found only in extremophiles and is the only such protein that is fused to a copper chaperone. Surprisingly, optical, electron paramagnetic resonance, and x-ray absorption spectroscopic data indicate the presence of a [2Fe-2S] cluster in CopZ-NT. The intact CopZ protein binds two copper ions, one in each domain. The 1.8 A resolution crystal structure of CopZ-NT reveals that the [2Fe-2S] cluster is housed within a novel fold and that the protein also binds a zinc ion at a four-cysteine site. CopZ can deliver Cu+ to the A. fulgidus CopA N-terminal metal binding domain and is capable of reducing Cu2+ to Cu+. This unique fusion of a redox-active domain with a CXXC-containing copper chaperone domain is relevant to the evolution of copper homeostatic mechanisms and suggests new models for copper trafficking.
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{{ABSTRACT_PUBMED_17609202}}
==About this Structure==
==About this Structure==
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[[Category: Iron-sufur protein]]
[[Category: Iron-sufur protein]]
[[Category: Metal transport]]
[[Category: Metal transport]]
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Revision as of 15:55, 28 July 2008

Image:2hu9.png

Template:STRUCTURE 2hu9

X-ray structure of the Archaeoglobus fulgidus CopZ N-terminal Domain

Template:ABSTRACT PUBMED 17609202

About this Structure

2HU9 is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Characterization and structure of a Zn2+ and [2Fe-2S]-containing copper chaperone from Archaeoglobus fulgidus., Sazinsky MH, LeMoine B, Orofino M, Davydov R, Bencze KZ, Stemmler TL, Hoffman BM, Arguello JM, Rosenzweig AC, J Biol Chem. 2007 Aug 31;282(35):25950-9. Epub 2007 Jul 3. PMID:17609202

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