2psr
From Proteopedia
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| - | [[Image:2psr.gif|left|200px]]<br /> | + | [[Image:2psr.gif|left|200px]]<br /><applet load="2psr" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2psr" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="2psr, resolution 2.05Å" /> | caption="2psr, resolution 2.05Å" /> | ||
'''HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)'''<br /> | '''HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2PSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 2PSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=CAA:Regulatory Ca2+ Binding Site'>CAA</scene> and <scene name='pdbsite=ZNA:Zn2+ Binding Site'>ZNA</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PSR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zn-binding]] | [[Category: zn-binding]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:13:36 2007'' |
Revision as of 18:03, 18 December 2007
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HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)
Overview
The crystal structure of human psoriasin (S100A7) in the native, calcium-bound form has been determined from two crystal forms of the, protein crystallized with and without divalent zinc. The overall, structures of the dimeric protein closely resemble the previously, determined holmium-substituted structure. The structures also reveal a, zinc-binding site of the protein, which is formed by three histidines and, an aspartate residue. Together, these residues coordinate the zinc ion in, a way similar to the pattern seen in certain metalloproteases and in, particular the collagenase family of proteins. Sequence comparison, suggests that this zinc site is present in a number of the remaining, members of the S100 family. The structure of S100A7 crystallized in the, absence of zinc further shows that loss of zinc results in a, reorganization of the adjacent empty and distorted EF-hand loop, causing, it to resemble a calcium-loaded EF-hand.
About this Structure
2PSR is a Single protein structure of sequence from Homo sapiens with CA and ZN as ligands. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states., Brodersen DE, Nyborg J, Kjeldgaard M, Biochemistry. 1999 Feb 9;38(6):1695-704. PMID:10026247
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