2huo

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{{STRUCTURE_2huo| PDB=2huo | SCENE= }}
{{STRUCTURE_2huo| PDB=2huo | SCENE= }}
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'''Crystal structure of mouse myo-inositol oxygenase in complex with substrate'''
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===Crystal structure of mouse myo-inositol oxygenase in complex with substrate===
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==Overview==
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Altered metabolism of the inositol sugars myo-inositol (MI) and d-chiro-inositol is implicated in diabetic complications. In animals, catabolism of MI and D-chiro-inositol depends on the enzyme MI oxygenase (MIOX), which catalyzes the first committed step of the glucuronate-xylulose pathway, and is found almost exclusively in the kidneys. The crystal structure of MIOX, in complex with MI, has been determined by multiwavelength anomalous diffraction methods and refined at 2.0-A resolution (R=0.206, Rfree=0.253). The structure reveals a monomeric, single-domain protein with a mostly helical fold that is distantly related to the diverse HD domain superfamily. Five helices form the structural core and provide six ligands (four His and two Asp) for the di-iron center, in which the two iron atoms are bridged by a putative hydroxide ion and one of the Asp ligands, Asp-124. A key loop forms a lid over the MI substrate, which is coordinated in bidentate mode to one iron atom. It is proposed that this mode of iron coordination, and interaction with a key Lys residue, activate MI for bond cleavage. The structure also reveals the basis of substrate specificity and suggests routes for the development of specific MIOX inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_17012379}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17012379 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17012379}}
==About this Structure==
==About this Structure==
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[[Category: Hd domain fold]]
[[Category: Hd domain fold]]
[[Category: Protein-substrate complex]]
[[Category: Protein-substrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:44:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:57:37 2008''

Revision as of 02:57, 28 July 2008

Image:2huo.png

Template:STRUCTURE 2huo

Crystal structure of mouse myo-inositol oxygenase in complex with substrate

Template:ABSTRACT PUBMED 17012379

About this Structure

2HUO is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism., Brown PM, Caradoc-Davies TT, Dickson JM, Cooper GJ, Loomes KM, Baker EN, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15032-7. Epub 2006 Sep 29. PMID:17012379

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