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2hwk

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[[Image:2hwk.gif|left|200px]]
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{{STRUCTURE_2hwk| PDB=2hwk | SCENE= }}
{{STRUCTURE_2hwk| PDB=2hwk | SCENE= }}
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'''Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain'''
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===Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain===
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==Overview==
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Alphavirus replication and propagation is dependent on the protease activity of the viral nsP2 protein, which cleaves the nsP1234 polyprotein replication complex into functional components. Thus, nsP2 is an attractive target for drug discovery efforts to combat highly pathogenic alphaviruses. Unfortunately, antiviral development has been hampered by a lack of structural information for the nsP2 protease. Here, we report the crystal structure of the nsP2 protease (nsP2pro) from Venezuelan equine encephalitis alphavirus determined at 2.45 A resolution. The protease structure consists of two distinct domains. The nsP2pro N-terminal domain contains the catalytic dyad cysteine and histidine residues organized in a protein fold that differs significantly from any known cysteine protease or protein folds. The nsP2pro C-terminal domain displays structural similarity to S-adenosyl-L-methionine-dependent RNA methyltransferases and provides essential elements that contribute to substrate recognition and may also regulate the structure of the substrate binding cleft.
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The line below this paragraph, {{ABSTRACT_PUBMED_16962975}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16962975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16962975}}
==About this Structure==
==About this Structure==
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[[Category: Multi-domain]]
[[Category: Multi-domain]]
[[Category: Rossman fold]]
[[Category: Rossman fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:48:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:41:04 2008''

Revision as of 04:41, 28 July 2008

Image:2hwk.png

Template:STRUCTURE 2hwk

Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain

Template:ABSTRACT PUBMED 16962975

About this Structure

2HWK is a Single protein structure of sequence from Venezuelan equine encephalitis virus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease., Russo AT, White MA, Watowich SJ, Structure. 2006 Sep;14(9):1449-58. PMID:16962975

Page seeded by OCA on Mon Jul 28 07:41:04 2008

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