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2hwr

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{{STRUCTURE_2hwr| PDB=2hwr | SCENE= }}
{{STRUCTURE_2hwr| PDB=2hwr | SCENE= }}
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'''Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists'''
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===Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists===
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==Overview==
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Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists.
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(as it appears on PubMed at http://www.pubmed.gov), where 17034149 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17034149}}
==About this Structure==
==About this Structure==
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[[Category: Ligand binding protein]]
[[Category: Ligand binding protein]]
[[Category: Ppar]]
[[Category: Ppar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:48:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:12:40 2008''

Revision as of 17:12, 27 July 2008

Image:2hwr.png

Template:STRUCTURE 2hwr

Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists

Template:ABSTRACT PUBMED 17034149

About this Structure

2HWR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists., Mahindroo N, Peng YH, Lin CH, Tan UK, Prakash E, Lien TW, Lu IL, Lee HJ, Hsu JT, Chen X, Liao CC, Lyu PC, Chao YS, Wu SY, Hsieh HP, J Med Chem. 2006 Oct 19;49(21):6421-4. PMID:17034149

Page seeded by OCA on Sun Jul 27 20:12:40 2008

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