2hwv

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[[Image:2hwv.gif|left|200px]]
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{{STRUCTURE_2hwv| PDB=2hwv | SCENE= }}
{{STRUCTURE_2hwv| PDB=2hwv | SCENE= }}
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'''Crystal structure of an essential response regulator DNA binding domain, VicRc in Enterococcus faecalis, a member of the YycF subfamily.'''
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===Crystal structure of an essential response regulator DNA binding domain, VicRc in Enterococcus faecalis, a member of the YycF subfamily.===
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==Overview==
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The response regulator VicR from the Gram-positive bacterium Enterococcus faecalis forms part of the two-component signal transduction system of the YycFG subfamily. The structure of the DNA-binding domain of VicR, VicR(c), has been solved and belongs to the winged helix-turn-helix family. It is very similar to the DNA-binding domains of Escherichia coli PhoB and OmpR, despite low sequence similarity, but differs in two important loops. The alpha-loop, which links the two helices of the helix-turn-helix motif, is similar to that of PhoB, where it has been implicated in contacting the sigma subunit of RNA polymerase, but differs from that of OmpR. Conversely, the loop following the helix-turn-helix motif is similar to that of OmpR and differs from that of PhoB. YycF/VicR, PhoB and Bacillus subtilis PhoP regulators all recognize almost identical DNA sequences and although there is currently no experimental evidence linking this loop with the DNA, the structure is consistent with possible involvement in selective DNA recognition or binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 17242520 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17242520}}
==About this Structure==
==About this Structure==
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[[Category: Dna-binding domain]]
[[Category: Dna-binding domain]]
[[Category: Essential response regulator]]
[[Category: Essential response regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:48:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:18:45 2008''

Revision as of 20:18, 27 July 2008

Image:2hwv.png

Template:STRUCTURE 2hwv

Crystal structure of an essential response regulator DNA binding domain, VicRc in Enterococcus faecalis, a member of the YycF subfamily.

Template:ABSTRACT PUBMED 17242520

About this Structure

2HWV is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.

Reference

Structure of the response regulator VicR DNA-binding domain., Trinh CH, Liu Y, Phillips SE, Phillips-Jones MK, Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):266-9. Epub 2007, Jan 16. PMID:17242520

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